2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156818
    TNIK-IN-7
    		Inhibitor 99.65%
    TNIK-IN-7 (Compound 8) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC50 of 11 nM, that has antitumor activity.
    TNIK-IN-7
  • HY-137814
    4-Nitrophenyl 4-guanidinobenzoate hydrochloride
    		99.38%
    4-Nitrophenyl 4-guanidinobenzoate (NPGB) hydrochloride is a potent sperm acrosin inhibitor, and also a trypsin substrate.
    4-Nitrophenyl 4-guanidinobenzoate hydrochloride
  • HY-122805
    PF-794
    		Inhibitor 99.19%
    PF-794 is a potent, selective and ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with an IC50 of 39 nM. PF-794 shows selective for the TNIK family. PF-794 reduces endogenous p120-catenin phosphorylation in cells. PF-794 can be used for teh study of psychiatric disorders.
    PF-794
  • HY-E70226
    Cathepsin S, human
    Cathepsin S, human, is a potent cysteine protease that promotes the degradation of damaged or harmful proteins in the endolysosomal pathway. Cathepsin S, human, is involved in multiple pathological processes, including arthritis, cancer, and cardiovascular disease.
    Cathepsin S, human
  • HY-129263
    L-Isoleucyl-L-valine
    L-Isoleucyl-L-valine (Ile-Val) is a dipeptide that induces the bovine trypsinogen-trypsin transition.
    L-Isoleucyl-L-valine
  • HY-P4476
    Suc-AAPA-pNA
    		Substrate 98.19%
    Suc-AAPA-pNA is a substrate for chymotrypsin A and elastase. Suc-AAPA-pNA can be used for enzyme activity assay.
    Suc-AAPA-pNA
  • HY-P4462
    D-Leu-Thr-Arg-pNA
    		Substrate 98.08%
    D-Leu-Thr-Arg-pNA is a substrate for γ-Tryptase, and can be used to measure the effects of small molecule inhibitors on γ-Tryptase activity.
    D-Leu-Thr-Arg-pNA
  • HY-126361A
    ZK824190 hydrochloride
    		Inhibitor 99.42%
    ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.
    ZK824190 hydrochloride
  • HY-148073
    MeO-Succ-Arg-Pro-Tyr-AMC TFA
    		Substrate 98.21%
    MeO-Succ-Arg-Pro-Tyr-AMC TFA is a fluorogenic peptide substrate for chymotrypsin-like proteases that detects protease activity. (measured at 460 nm)
    MeO-Succ-Arg-Pro-Tyr-AMC TFA
  • HY-W783268
    Matriptase-IN-2 free base
    		Inhibitor
    Matriptase-IN-2 free base is a matriptase inhibitor with a Ki of 5 nM. Matriptase-IN-2 has the potential for musculoskeletal system disorder research (WO2011023958A1; compound 432).
    Matriptase-IN-2 free base
  • HY-W231513
    MASTL/Aurora A-IN-1
    		Inhibitor 99.47%
    MASTL/Aurora A-IN-1 (Compound MA4) is a dual inhibitor of MASTL and Aurora A kinases with IC50 values of 0.56 μM and 0.16 μM, respectively. MASTL/Aurora A-IN-1 has broad-spectrum anticancer activity and has potent anticancer activity against SR (leukemia), K-562 (leukemia), MDA-MB-435 (melanoma), MOLT-4 (leukemia), and SK-MEL-2 (melanoma) cell lines in NCI-60 cancer cell lines with GI50 values of 0.023, 0.032, 0.037, 0.044, and 0.051 μM, respectively. MASTL/Aurora A-IN-1 inhibits Aurora A and MASTL kinases, inducing cell cycle G2/M arrest, thereby inhibiting cancer cell proliferation. MASTL/Aurora A-IN-1 can be used in cancer research, especially for tumors with dysregulated mitosis.
    MASTL/Aurora A-IN-1
  • HY-130136A
    TMPRSS6-IN-1 TFA
    		Inhibitor
    TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice.
    TMPRSS6-IN-1 TFA
  • HY-P990387
    Anti-CTSS/Cathepsin S Antibody (Fsn0503h)
    		99.28%
    The Anti-CTSS/Cathepsin S Antibody (Fsn0503h) is a humanized antibody expressed in CHO cells, targeting CTSS/Cathepsin S. The Anti-CTSS/Cathepsin S Antibody (Fsn0503h) has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CTSS/Cathepsin S Antibody (Fsn0503h) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CTSS/Cathepsin S Antibody (Fsn0503h)
  • HY-134445
    N-Benzoyl-L-tyrosine p-nitroanilide
    N-Benzoyl-L-tyrosine p-nitroanilide is a chymotrypsin substrate.
    N-Benzoyl-L-tyrosine p-nitroanilide
  • HY-P990617
    Anti-Hepcidin/HAMP Antibody (LY2787106)
    		Inhibitor 98.23%
    Anti-Hepcidin/HAMP Antibody (LY2787106) is a CHO-expressed human antibody that targets Hepcidin/HAMP.Anti-Hepcidin/HAMP Antibody (LY2787106) has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 144.2 kDa. The isotype control for Anti-Hepcidin/HAMP Antibody (LY2787106) can be referred to as Human IgG4 kappa, Isotype Control (HY-P99003).
    Anti-Hepcidin/HAMP Antibody (LY2787106)
  • HY-176518
    ssPalmE-P4-C2
    		98.81%
    ssPalmE-P4-C2 is a SS-cleavable and pH-sensitive lipid-like material (ssPalm) with a vitamin E‑scaffold. ssPalmE-P4-C2 improves gene knockdown activity against FVII with an ED50 of 0.5 mg/kg. ssPalmE-P4-C2 can be used to synthesize lipid nanoparticles (LNPs) for delivering siRNA to the hepatocyte. ssPalmE-P4-C2 can be used for the RNA therapies for dyslipidemia, hepatitis B/C infections and transthyretin amyloidosis research.
    ssPalmE-P4-C2
  • HY-P2942
    Chymotrypsinogen
    Chymotrypsinogen is an inactive precursor of Chymotrypsin (HY-108910). Chymotrypsin is a serine protease produced by the pancreas.
    Chymotrypsinogen
  • HY-P11335A
    Oscillamide Y TFA
    		Inhibitor 98.18%
    Oscillamide Y TFA is the trifluoroacetate salt of Oscillamide Y (HY-P11335). Oscillamide Y (Compound 1), a ureido-containing cyclic peptide, is a Chymotrypsin inhibitor. Oscillamide Y can be isolated from freshwater toxic cyanobacterium Oscillatoria agardhii. Oscillamide Y has potent toxicity against fish, daphnid magna and algae with a stimulatory effect for Raphidocelis subcapitata (EC50: 4.62 mg/L). Oscillamide Y induces high luminescence inhibition in Aliivibrio fischeri. Oscillamide Y can be used for ecological development research.
    Oscillamide Y TFA
  • HY-14853
    Darexaban
    		Inhibitor 98.05%
    Darexaban (YM150) is a potent, selective and orally active factor Xa (FXa) inhibitor with an IC50 of 54.6 nM. Darexaban shows high selectivity against other related serine proteases, such as trypsin, thrombin, and kallikrein. Darexaban has anticoagulant and antithrombotic effects.
    Darexaban
  • HY-P2828
    [Des-Pro2]-Bradykinin
    		Inhibitor 99.68%
    [Des-Pro2]-Bradykinin is a protease inhibitor. [Des-Pro2]-Bradykinin prevents the degradation of methionine enkephalin.
    [Des-Pro2]-Bradykinin
Cat. No. Product Name / Synonyms Application Reactivity